This page will be updated as internal discussions of best options proceed. Thank you for sending us your thoughts at To allow us to identify your message(s) please place "Study Improvements" in the subject line. Your doctors are cordially invited to join this conversation.

Caution: Nutrient combinations can cause overdoses. Therefore it is best to proceed ONLY with the advice of your doctors. Even B vitamins have been shown to increase strokes, heart attacks and sudden death attributed to coronary artery disease. See this link for details of B vitamin toxicity when incorrect levels are consumed.
To examine a published, peer-reviewed, high level discussion of the following longevity candidate nutrients and medicines see this link: acarbose, deprenyl, d-glucosamine, dihydroergocristine methanesulfonate, ellagic acid, fenofibrate, glutathione, metformin, spermidine, tyrosol, and vinpocetine. Of these candidates, d-glucosamine has been identified as the safest and for this reason is at the top of our list for addition to the Blueberry Health Study. We have not yet applied for authorization to add it to the study because despite its apparent safety there is a chance it might cause harmful effects in combination with blueberry smoothies for sensitive individuals. Therefore high levels of caution and regular safety checks are under consideration and will be required if and when we decide to study its possible longevity benefits.

When asked what senior citizens can do to maintain and improve their health, scientists who answered this question during six American Aging Association annual meetings recommended the following supplements and strategies.

This list is open for review and comment.  Please be sure to discuss these recommendations with a physician or other health professional who is familiar with your medications and personal health history before trying any of them.

To send positive or negative comments, about any item on this list, simply click here.  Thank you.

During the 2008 annual meeting, the only new strategies we heard recommended were walnuts and pterostilbene-containing fruits including blueberries.  Jim Joseph and collaborators obtained evidence of benefits from both walnut polyphenols and pterostilbene, which actually “beat” resveratrol in their experiments.  A number of new combinations were recommended however, including vitamin E and coenzyme Q10, blueberries and spinach, and blueberries and N-acetylcysteine.  The combination of blueberries and N-acetylcysteine was questioned however, because of a publication linking N-acetylcysteine with pulmonary hypertension.

There is a possibility that either spinach, which is relatively rich in glutathione, or the glutathione-precursor N-acetylcysteine, should be consumed along with daily blueberries to reduce glutathione depletion that may occur in susceptible individuals when blueberry polyphenols are excreted following glutathione-conjugation.  Regular consumption of spinach or N-acetylcysteine could also counteract the beneficial effects of blueberries if too great a dose of polyphenols or antioxidants is consumed.  Further research is needed to determine whether these combinations provide greater benefits than either alone, or instead reduce benefits to humans.

Dr. C. David Rollo’s combination of 31 nutrients, the largest combination we have ever seen investigated for long-term health benefits, has been added to this list in the form of a figure [below] which has been amended to avoid copyright violations.




Acetyl-L-carnitine and lipoic acid

All food groups should be taken in moderation

Alpha-lipoic acid (racemic)

Antioxidants: Kinetically active antioxidants like lipoic acid, cysteine and

Antioxidants: low dose


Arginine – see web link 1

Arginine-rich foods


Aspirin – 4 times/wk

Aspirin (1/2 baby aspirin daily)



Avoid "AGEs" (sugar glycation/glycooxidation products) in browned foods


Benfotiamine – see web link 1


Berries – blueberries

Berries – blueberries – concentrated extract – from Life Extension Foundation

Berries – blueberries (1 cup daily)

Berries – blueberries (2 cups daily)

Berries – blueberry juice

Berries – blueberry preserves



BMI – keep body mass index close to 25


Brussels sprouts



Calcium + vitamin D

Calcium 1500 mg/d

Calcium in CaCO3

Calorie restriction – eat ad lib one day, alternate to eat 1/3 less on the next day –Canteloupe

Carnosine – see web link 1



Chew food well or process




Chondroitin sulfate

Chromium in Cr picolinate – 100-200 ug

Coenzyme Q10

Coenzyme Q10 1,000 mg/dy

Coenzyme Q10 150 mg/dy

Coenzyme Q10 and vitamin E in combination

Colored foods

Creatine monohydrate



Depression reduction


DMAE Bitartrate



Essential amino acids

Exercise – 20 minutes of exercise daily

Exercise – 30 min daily – need not be more vigorous than walking

Exercise – 30-90 min/dy outdoors when possible

Exercise – as much as practical, the more the better –

Exercise – breathing exercise

Exercise – daily

Exercise – dancing

Exercise – every day as tolerated

Exercise – light walking

Exercise – mini-trampoline

Exercise – moderate

Exercise – moderate physical activity

Exercise – more than 30 min aerobic activity every day –

Exercise – physical activity, fencing, with swords and foil, 3 –

Exercise – power walking

Exercise – resistance

Exercise – strength training 2-3 times a week

Exercise – strength training to increase muscle mass

Exercise – stretching

Exercise – swim

Exercise – three kinds – stretching, such as yoga, resistance, such as lifting
   weights, push ups and pull ups, and cardiovascular, such as walking,
   swimming, dancing, Aikido, and horseback riding

Exercise – to "mildly out of breath"

Exercise – walk

Exercise – weight lifting

Exercise – with weights

Fats – Monounsaturated fats

Fats – Polyunsaturated and monounsaturated fats

Fiber – high fiber foods

Fish – two to three servings each week
Fish – about five servings each week

Fish oil – 15 ml/dy

Fish oil – 2 g

Fish oil – omega-3

Fish oil – walmart brand – 5x/wk

Fish, cold water

Fish, deep water

Flax oil

Flax seed

Folic acid (400 ug/dy)

Folic acid 1,200 ug,

Folic acid 800 ug,


Fruits (fresh or frozen),

Fruits and vegetables

Fruits and vegetables, colorful, not white food groups –

Fruits and vegetables, fresh

Fruits and vegetables, fresh whole organic

Fruits and vegetables, preferably organic, increase amount and


Genox/kronos profile – give them what they need

Get interested in life

Gingko biloba


Good oils vs bad oils

Granola – homemade 

Grape juice

Grape juice, purple

Grapes, purple

Healthy diet

Honey (mixed with yeast and water)

Huperzine A


Inositol – 5 to 6 gms

Juice Plus


Laugh, tell jokes

Less calories the next day, keep alternating

Lipoic acid


Magnesium in Mg Orotate

Magnesium in Mg Oxide

Melatonin – 0.1 mg

Melatonin – 3 mg

Melatonin – 3 times/wk

Melatonin 1, 2 then 3 mg/dy

Mental exercise –  crossword puzzles, jeopardy, change habits

Mental workout – learn something new (skills or facts) –

Mental workout – literature or an otherwise enriched environment.

Mental workout – use nondominant hand

Mental-cardio workout



Milk – lowfat

Milk/cream plus whole grain (i.e. Oatmeal with milk) –

MTV daily


Multivitamin – Centrum

Multivitamin – Centrum Silver

Multivitamin – Centrum Sport

Multivitamin – high-quality vitamin-mineral anti-aging supplement

Multivitamin – life extension

Multivitamin – longevital – swanson

Multivitamin – Pharmanex brand lifepak with coenzyme Q10 –

Multivitamin – Superbooster by Life Extension

Multivitamin with no iron

Mushrooms – Shitake

Musical instruments

N-acetyl cysteine

N-acetyl cysteine + phase II inducers


NSAID – at bedtime – nonsteroidal antiinflammatory drug


Nuts – almond butter

Nuts – almonds

Nuts – raw
Nuts – Walnuts



Olive oil


Omega 3

Omega 3 at 3-4 grams/day

Omega 3 fatty acids

Onions, red

Orange juice

Oranges and tangerines

PABA (para-amino benzoic acid)


Phase II inducers



Pomegranate juice

Positive imagery

Practice happiness

Profile to determine what each person needs

Protein – easily digested quality protein such as fish

Protein – high protein/low carb diet
Pterostilbene-containing foods


Pyridoxamine – see web link 1


Red wine extract, Longevinex

Red wine, 1 glass/day

Red wine, 2-3 glasses/day,


Ribose – d-ribose


Rice – brown



SAME – S-adenolsyl methionine


Saw palmetto


Sea weed – wakame, kombu (kelp)

Selenium – 100-200 ug


Social activities

Source of life by natures plus

Soy – Miso (soy bean paste)

Soy – Tempe

Soy – Tofu


Square dancing


Stress reduction

Super B complex

Taurine (2-4 gms)

Tea – black

Tea – green and black tea

Tea – green tea

Tea – green tea extract or egcg

Tea – green, white and black tea

Tomato sauce


Tomatoes – cooked

Variety, minimally processed foods

Vegetable juices, fresh



Vegetables – greens

Vitamin B complex

Vitamin B1, Thiamin – 150 mg

Vitamin B-12 400 ug

Vitamin B12, Cyanocobalamin – 150 mg

Vitamin B2, Riboflavin – 150 mg

Vitamin B3, Niacin – 250 mg

Vitamin B5, Pantothenate – 950 mg

Vitamin B6, Pyridoxine – 150 mg

Vitamin B-complex for brains

Vitamin C

Vitamin C – 500 mg

Vitamin C – 500 mg 2x/day

Vitamin C 2-6 grams

Vitamin C as Ascorbyl Palmitate – 600 mg

Vitamin C dose ranging to 1 g/dy

Vitamin C, 0.5 g

Vitamin C, 1500 mg daily

Vitamin D

Vitamin D 1000 units

Vitamin D 400-800 mg

Vitamin D3 – 1000 IU

Vitamin E
Vitamin E and coenzyme Q10 in combination

Vitamin E – 400 iu

Vitamin E 700 – 1000 iu

Vitamin E mixture – alpha, beta, delta and gamma forms

Vitamin E, beta-Tocopherol

Vitamin E, d-alpha-Tocopherol – 500 IU

Vitamin E, delta-Tocopherol – 67 mg

Vitamin E, gamma-Tocopherol 200 mg


Water – deionized water

Weight – keep consistent with body mass index close to 25 –

Wheat germ

Whey protein or essential amino acids

Whole foods especially low calorie high nutritent density –

Whole grains

Whole wheat


Wine – red

Yeast – Brewer's

Yeast – in honey and water


Zinc if low

Zinc in Zn gluconate

Suggested reading:


1) Web link –  

2) Web link –

3) Recommended reading – Consumer Reports, January 2005

4) Web link – John Furber's nutrition tips

Dr. Rollo’s “Formula 31”:

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